The point: silicone, polyurethane, and hybrid sealants all have a place. The right choice depends on substrate, movement, exposure, finish, and whether the area is wet, external, trafficable, paintable, or compliance-driven.
Silicone
Silicone is common for bathrooms, kitchens, laundries, splashbacks, glass, tile, and many internal finish lines. In wet areas, a suitable sanitary silicone is usually the starting point. Some substrates, including stone and specialty finishes, need extra care.
Polyurethane
Polyurethane sealants are common for external joints, concrete, facade work, movement joints, and commercial sealing. They can suit tougher exposure, movement, and paintability needs, but they still need correct prep and joint design.
Hybrid sealants
Hybrid and MS-polymer style sealants can be useful where adhesion, movement, weathering, and versatility matter. They are often considered for external or mixed-substrate jobs, depending on the exact product and joint.
Fire-rated sealants
Fire-rated work is different. The required product, tested system, joint type, backing, depth, and documentation expectations need to be confirmed for the project. Standard caulking is not a substitute for a fire-rated scope.
Choose from the joint, not the room name
Brandon would not choose product from the room name alone. He would check what the joint is between, how much it moves, whether it is exposed to water or UV, whether it needs paint, and whether old sealant has failed because the wrong product was used before.